Biomimetic surfaces and sensors for detection and inhibition of Covid-19 virus and antibodies
- Contact person:
- Börje Sellergren
- Malmö University
- Responsible at Malmö University:
- Börje Sellergren
- Project members:
- Daniel Aili - Linköping University
- Niklas Arnberg - Umeå University
- Time frame:
- 01 July 2020 - 31 March 2021
- Research environment :
- Research subject:
Improved testing technologies are in urgent demand to address current and future pandemics. Current assays for Covid-19 are divided into direct assays targeting the virus per se or indirect serological assays for detecting immunity - neither of these are perfect. This warrants the development of low-cost assays or biosensors (no expensive reagents) with short response time, high sensitivity and specificity and that can be quickly deployed in response to new pathogens.
In this project, we will use an entirely new approach to develop sensors with the above features. This is based on the use of Reversible Self-Assembled Monolayers (rSAMs) offering easily restorable surfaces for highly efficient virus or antibody catch and release. Coupling the rSAMs to electrochemical or optical transducers will provide sensors for ultrasensitive real time virus or antibody detection. rSAM nanoparticles will also be tested for inhibition of virus spike proteins adhering to ACE2 expressing endothelial cells.
The solution builds on an ongoing collaboration involving MaU, LiU and UmU researchers.
The aims of the project are:
- To develop rSAMs as dynamic surfaces for multivalent recognition of SARS-CoV-2 and anti-SARS antibodies.
- To study rSAM nanoparticles as inhibitors of spike protein adhesion to host cells.
- To develop robust electrochemical or nanoplasmonic sensors for antibody-free ultrasensitive and rapid in situ detection of viruses and antibodies.