Contact person:
Börje Sellergren
  • Swedish Research Council
Responsible at MaU:
Börje Sellergren
Project members:
  • Daniel Aili - Linköping University
Collaborators and other project members:
  • Swedish Research Council
Time frame:
01 February 2019 - 31 December 2022
Research environment :
Research subject:

About the project

The topic of this project concerns Reversible Selfassembled Monolayers (rSAMs) and their use as robust lipid bilayer mimics for bacterial pathogen inhibition and for controlled cell adhesion. This pH-switchable version of classical SAMs allow a reversible and ordered introduction of affinity reagents in a layered architecture.

As for traditional SAMs, the rSAM are tunable with respect to the nature of the head group and layer order and stability but contrasts with the former by featuring pH responsiveness and a lipid bilayer like fluidic nature.

The work performed thus far shows that this results in a range of unique supramolecular features e.g. strongly enhanced multivalent interactions, ultralow detection limits in virus and lectin sensing, surface restorability and pronounced and tunable modulation of cell-adhesion. This opens up new exciting areas of research that we intend to address in the coming four years.

Based on a focused work plan the main aims of the current proposal are threefold:

  1. To study rSAMs as a tunable fluidic biointerface for controlled cell adhesion, proliferation and differentiation, potentially impacting current tissue engineering efforts.
  2. To transfer rSAMs to nanoparticles in order to develop potent inhibitors of bacterial infection.
  3. To assess templated ligand fixation as an approach to enhance lectin affinity or to modulate cell adhesion.