Welcome to Jennu Engstredt Thesis of the Year lecture!

"When Lipids Meet Water: How Lipid Depots Take Shape"


What happens when lipids meet water? Some lipids contain both water-loving and water-repelling parts, causing them to spontaneously organize into different structures. In my thesis, I investigated how injectable lipid mixtures take up water, swell and reorganize, and how hydration affects both the structures that form and their distribution within the depot over time.

The lecture will be held in English. Fika will be served.
All lectures will be streamed. The link will be posted here before the lecture.

Jenni Engstedt
Faculty of Health and Society

'Structure, Phase Behaviour, and Swelling Kinetics of Lipid-Based Drug Delivery Depots'


This dissertation presents a systematic and rigorous experimental study of the relationships between structure and properties in lipid-based drug delivery systems. Using advanced techniques such as small-angle X-ray scattering (SAXS), magnetic resonance imaging (MRI), and Raman spectroscopy, Engstedt demonstrates how lipid composition and hydration control the formation of liquid crystalline phases, structural transitions, and dynamic behaviour in lipid depots.

The work is characterised by a high degree of originality, strong methodological quality, and a high level of independence. By combining several complementary techniques, a coherent framework is established for understanding and predicting the behaviour of lipid-based drug delivery systems.

The dissertation also has clear relevance to drug development, as demonstrated by studies of the compatibility between lipid formulations and active ingredients. Overall, the work represents high-quality, scientifically original research of international standard.