Presentation

My doctoral research explores the role of microorganisms and host immune responses in secondary chronic osteomyelitis of the jaw and medication-related osteonecrosis of the jaw (MRONJ). These conditions are challenging to treat and may develop in association with dental infections or following oral surgical procedures. MRONJ is associated with certain medications, particularly antiresorptive agents. The microbial and immune mechanisms contributing to persistent jawbone inflammation and impaired bone healing are not yet fully understood.

The project examines associations between the microbial composition of jawbone and blood-based inflammatory and immune markers. The aim is to identify potential biomarkers and disease-associated microorganisms that could improve understanding of disease progression and inform individualised treatment. Emphasis is placed on guiding antibiotic selection and reducing unnecessary or ineffective antibiotic use to promote healing and improve treatment outcomes.

The project is conducted in collaboration with the Department of Oral and Maxillofacial Surgery at Skåne University Hospital in Lund, the Oral Biology laboratory environment at Malmö University, and collaborators in infection medicine at Lund University.

My research network also includes membership in the National Doctoral Programme in Infection and Antimicrobials (NDPIA).

Publications