Speaker

Anil Incel, Department of Biomedical Science, Malmö University

Talk overview

Most biofunctional interfaces are intrinsically static. Once a recognition element is immobilized, its accessibility is usually fixed regardless of changes in sample composition or measurement conditions. This talk focuses on whether thermoresponsive polymer architectures can be used to reversibly regulate access to surface-bound antibodies and aptamers in a manner that depends on target size and interface design. Using antibody-functionalized beads and aptamer-modified nanoporous gold electrodes as two contrasting platforms, the work explores how temperature-driven polymer transitions alter binding-site accessibility, and how the outcome depends on polymer architecture, interface format, and analyte size. The broader aim is to understand how reversible interfacial control can be used to either expose or protect recognition sites depending on the analytical requirement.

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