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Presentation
Enzymatic activity in oral biofilms – biotechnological applications and putative predictive biomarkers for oral disease
While several studies have advanced our knowledge regarding the microbial composition in the oral flora in health and disease, the underlying role of enzymes and their regulation has mainly been disregarded. Herein, I will investigate the impact of glycosidase expression in oral flora during health/disease. My studies are expected to lead to the identification of novel biomarkers for oral health and disease, an area in need of novel, rapid and robust methods for diagnosis and novel biotechnological tools as analytical reagents for biopharmaceuticals.
Publications
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2025 | Doctoral thesis, comprehensive summary
Breaking the Barrier – Insights into Mucin-Degrading Proteases in Oral Bacteria
Fredrik Leo
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2025 | Article in journal
Functional divergence of MdpS and MdpS2 reveals mucin-targeting strategies in Streptococcus oralis
Fredrik Leo, Jonas Nilsson, Liisa Arike, Sahana Kumar, Emma Hilton, Rolf Lood, David J. Thornton, Gregg A. Duncan, Gunnel Svensäter, Claes Wickström
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2024 | Article in journal
Characterization of MdpS: an in-depth analysis of a MUC5B-degrading protease from Streptococcus oralis
Fredrik Leo, Rolf Lood, Kristina A. Thomsson, Jonas Nilsson, Gunnel Svensäter, Claes Wickström
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2023 | Article in journal
Characterization of a highly conserved MUC5B-degrading protease, MdpL, from Limosilactobacillus fermentum
Fredrik Leo, Gunnel Svensäter, Rolf Lood, Claes Wickström