You are warmly invited to attend the BRCB afternoon seminar "Exploring Lipids with Mass Spectrometry: Quantitative, Untargeted, and Spatial Approaches".

Presenters

Dr. Otto Savolainen, Head of Division, Chalmers Mass Spectrometry Infrastructure
Dr. Jayesh Kattla, Waters Sweden

Talk overview

Lipids play diverse and critical roles in biological systems, yet their structural diversity, dynamic range, and spatial heterogeneity pose significant analytical challenges. Mass spectrometry (MS) has become a cornerstone technology in lipidomics, enabling sensitive, selective, and information‑rich analysis across a wide range of lipid classes and biological contexts.

In this seminar, we will provide an overview of why mass spectrometry is essential for modern lipidomics research, followed by a practical introduction to key MS‑based lipidomics approaches. Topics include targeted lipidomics for quantitative analysis of defined lipid panels, and untargeted lipidomics strategies for discovering unexpected lipids and exploring “unknown unknowns” in complex biological samples. We will also discuss mass spectrometry imaging as a tool to reveal the precise spatial distribution of lipids directly within tissues. Finally, emerging applications of charged detection mass spectrometry for the analysis of large lipid‑associated molecules, such as apolipoproteins, will be introduced.

The talk is intended for researchers interested in lipid biology, analytical chemistry, and translational research, and aims to provide conceptual understanding rather than platform‑specific or commercial perspectives.

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