Temporomandibular dysfunction is an umbrella term for conditions in the masticatory apparatus that affect approximately 30% of the adult population. Conditions in the temporomandibular joint (TMJ) mostly do not require surgical treatment. Advanced pathology in the temporomandibular joint may be subject to surgical treatment to restore function, possibly reduce pain, and thereby improve health and quality of life. Several temporomandibular joint surgical procedures have been used historically. Plastic surgical interventions in the temporomandibular joint with grafts or implants are used in so-called "end-stage" conditions of jaw joint disease.

The aim of this research project is to investigate the scientific support for the surgical treatment of the TMJ by Total Joint Replacement. Specific aims are: - To examine the scientific evidence for treatment of severe TMJ dysfunction with alloplastic total joint replacement with a systematic literature review. - To study the changes in health-related quality-of-life in a cohort of patients treated with TJR with alloplastic joint prosthesis - To investigate the use of social security benefits in patients treated with TJR with alloplastic joint prosthesis. - To study the cost-effectiveness of the treatment TJR with alloplastic joint prosthesis.