Presentation
Throughout my career, I have held a deep fascination for the aggregation of proteins and peptides and their intricate connections to various physiological and pathological processes. At present, my research is centered on exploring aggregation as a novel mechanism of host defense, specifically in the context of skin inflammation and wound healing. My primary focus lies in investigating the host defense properties of blood proteins from the apolipoprotein family, with a special emphasis on apolipoprotein E, often abbreviated as ApoE.
Our research findings have unveiled a hitherto undiscovered role for ApoE, involving the aggregation of endotoxins and bacteria. This remarkable ability facilitates the clearance of bacterial toxins and the effective elimination of microbial threats. Furthermore, the association between host defense and aggregation implies that persistent inflammation might disrupt the proper activation of these protein-based defense pathways. As a result, our research also sheds light on the intriguing interplay between antimicrobial and amyloidogenic peptides. Additionally, it will enhance our comprehension of various amyloid-related diseases affecting not only the skin but also other organs, including the brain.
