We use cookies on this website. Cookies help us deliver the best experience on our website. Read about cookies.
-
- Education
- Education
- Programmes and courses
- Applications and admissions
- Tuition fees
- Scholarships
- Exchange studies at Malmö University
- Study Guidance
-
- After admission
- After admission
- Moving to Malmö
- Pre-orientation
- Arrival guide
-
- About studies at Malmö University
- About studies at Malmö University
- Why choose Malmö University
- Understanding university studies
- Connect with current students
On the page -
- Research
- Research
-
- Doctoral studies
- Doctoral studies
- Doctoral courses
-
- Doctoral schools
- Doctoral schools
- Education, Learning and Globalisation
- Doctoral school: Learning in Multicultural Societal Contexts
- Swedish National Graduate School in Science and Technology Education Research
- Doctoral school: Relevancing Mathematics and Science Education (RelMaS)
- Doctoral school: Sustainable Movement Education
- Finding ways in a time of great future challenges (FinnFram)
- Doctoral school: Pedagogy and Vocational Skills
- Doctoral school: Culturally Empowering Education through Language and Literature
- Research subjects
-
- Prominent research
- Prominent research
-
- Research publications
- Research publications
- Search publications
- Malmö University Press
- Research events
- Be part of research
On the page -
- Collaboration and Innovation
- Collaboration and Innovation
- Areas of collaboration
- Innovation
- Collaboration with students
-
- Collaborate with researchers
- Collaborate with researchers
- Labs and facilities
- Culture collaboration
- Support Malmö University
On the page -
- About us
- About us
-
- Job opportunities
- Job opportunities
- Current vacancies
- Meet our staff
- Employee benefits
-
- Faculties and departments
- Faculties and departments
-
- Faculty of Culture and Society
- Faculty of Culture and Society
- Department of Urban Studies
- Department of Global Political Studies
- School of Arts and Communication
-
- Faculty of Education and Society
- Faculty of Education and Society
- Department of Childhood, Education and Society
- Department of Sports Sciences
- Department of Natural Science, Mathematics and Society
- Department of School Development and Leadership
- Department of Culture, Languages and Media
- Department of Society, Culture and Identity
-
- Faculty of Technology and Society
- Faculty of Technology and Society
- Department of Computer Science and Media Technology
- Department of Materials Science and Applied Mathematics
- Faculty of Odontology
-
- Contact Malmö University
- Contact Malmö University
- Visit Malmö University
- Map of the buildings (Google Maps)
- Merchandise
- Whistleblowing
- News and press
- Management and decision-making paths
-
- Vision, objectives and strategy 2025
- Vision, objectives and strategy 2025
- Global engagement
- Sustainability
- Widened recruitment and participation
- Quality work at the University
- Apartments for researchers
-
- Malmö Academic Choir and Orchestra
- Malmö Academic Choir and Orchestra
- Student work - video pieces
- Alumni & Friends
- Annual Academic Celebration
-
- University Dental Clinic
- University Dental Clinic
- About the University Dental Clinic
- The University in a troubled world
On the page
Presentation
Throughout my career, I have held a deep fascination for the aggregation of proteins and peptides and their intricate connections to various physiological and pathological processes. At present, my research is centered on exploring aggregation as a novel mechanism of host defense, specifically in the context of skin inflammation and wound healing. My primary focus lies in investigating the host defense properties of blood proteins from the apolipoprotein family, with a special emphasis on apolipoprotein E, often abbreviated as ApoE.
Our research findings have unveiled a hitherto undiscovered role for ApoE, involving the aggregation of endotoxins and bacteria. This remarkable ability facilitates the clearance of bacterial toxins and the effective elimination of microbial threats. Furthermore, the association between host defense and aggregation implies that persistent inflammation might disrupt the proper activation of these protein-based defense pathways. As a result, our research also sheds light on the intriguing interplay between antimicrobial and amyloidogenic peptides. Additionally, it will enhance our comprehension of various amyloid-related diseases affecting not only the skin but also other organs, including the brain.
Publications
-
2022 | Article in journal
Antibacterial and Anti-Inflammatory Effects of Apolipoprotein E
Manoj Puthia, Jan K. Marzinek, Ganna Petruk, Gizem Ertürk Bergdahl, Peter J. Bond, Jitka Petrlova
-
2022 | Article in journal
SARS‐CoV‐2 spike protein aggregation is triggered by bacterial lipopolysaccharide
Jitka Petrlova, Firdaus Samsudin, Peter J. Bond, Artur Schmidtchen
-
2021 | Article in journal
The role of full-length apoE in clearance of Gram-negative bacteria and their endotoxins
Ganna Petruk, Malin Elvén, Erik Hartman, Mina Davoudi, Artur Schmidtchen, Manoj Puthia, Jitka Petrlova
-
2020 | Article in journal
A dual-action peptide-containing hydrogel targets wound infection and inflammation
Manoj Puthia, Marta Butrym, Jitka Petrlova, Ann-Charlotte Strömdahl, Madelene Å. Andersson, Sven Kjellström, Artur Schmidtchen
-
2020 | Article in journal
Thrombin-derived C-terminal fragments aggregate and scavenge bacteria and their proinflammatory products
Jitka Petrlova, Ganna Petruk, Roland G. Huber, Eilish W. McBurnie, Mariena J.A. van der Plas, Peter J. Bond, Manoj Puthia, Artur Schmidtchen