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On the page
Presentation
Throughout my career, I have held a deep fascination for the aggregation of proteins and peptides and their intricate connections to various physiological and pathological processes. At present, my research is centered on exploring aggregation as a novel mechanism of host defense, specifically in the context of skin inflammation and wound healing. My primary focus lies in investigating the host defense properties of blood proteins from the apolipoprotein family, with a special emphasis on apolipoprotein E, often abbreviated as ApoE.
Our research findings have unveiled a hitherto undiscovered role for ApoE, involving the aggregation of endotoxins and bacteria. This remarkable ability facilitates the clearance of bacterial toxins and the effective elimination of microbial threats. Furthermore, the association between host defense and aggregation implies that persistent inflammation might disrupt the proper activation of these protein-based defense pathways. As a result, our research also sheds light on the intriguing interplay between antimicrobial and amyloidogenic peptides. Additionally, it will enhance our comprehension of various amyloid-related diseases affecting not only the skin but also other organs, including the brain.
Publications
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2024 | Article in journal
Thrombin-derived C-terminal peptides bind and form aggregates with sulfated glycosaminoglycans
Ganna Petruk, Jitka Petrlova, Firdaus Samsudin, Peter J. Bond, Artur Schmidtchen
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2023 | Article in journal
Targeting Toll-like receptor-driven systemic inflammation by engineering an innate structural fold into drugs
Ganna Petruk, Manoj Puthia, Firdaus Samsudin, Jitka Petrlova, Franziska Olm, Margareta Mittendorfer, Snejana Hyllén, Dag Edström, Ann-Charlotte Strömdahl, Carl Diehl, Simon Ekström, Björn Walse, Sven Kjellström, Peter J. Bond, Sandra Lindstedt, Artur Schmidtchen
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2022 | Article in journal
Antibacterial and Anti-Inflammatory Effects of Apolipoprotein E
Manoj Puthia, Jan K. Marzinek, Ganna Petruk, Gizem Ertürk Bergdahl, Peter J. Bond, Jitka Petrlova
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2022 | Article in journal
SARS‐CoV‐2 spike protein aggregation is triggered by bacterial lipopolysaccharide
Jitka Petrlova, Firdaus Samsudin, Peter J. Bond, Artur Schmidtchen
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2021 | Article in journal
The role of full-length apoE in clearance of Gram-negative bacteria and their endotoxins
Ganna Petruk, Malin Elvén, Erik Hartman, Mina Davoudi, Artur Schmidtchen, Manoj Puthia, Jitka Petrlova