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On the page
Börje
Sellergren
Professor, directly appointed
borje.sellergren@mau.se
+46 40 665 78 10
orcid.org/0000-0002-2392-3305
Presentation
Professor Sellergrens research expertise span over supramolecular chemistry, molecular recognition and separation science. Based on rational chemical design, molecular self-assembly and imprinting, abiotic receptors are designed and used in affinity techniques for molecular biomarker analysis and discovery, pathogen inhibition and sensing, cell imaging, extracellular matrix imitations and therapeutics. Both “lock-and-key” and multivalent recognition concepts are being pursued. In the former case, molecular imprinting is used to produce robust receptors (MIPs), often exhibiting antibody-like recognition behaviour with nanomolar or higher affinities for biomolecular targets. Larger objects such as viruses or cells are instead targeted using dynamic multivalent receptors in the form of reversible self-assembled monolayers (rSAMs). This membrane mimetic plug and play approach is used to design dynamic virus or bacterial receptors featuring exceptionally high affinities that are currently explored as inhibitors, cell modulators or sensors. Sellergren has published over 190 scientific publications and 15 patents (H-index: 62) in the field of molecular imprinting and biomimetic chemistry with notable contributions reporting robust lipid bilayer mimetics, protein and peptide imprinting, PTM affinity engineering, combinatorial imprinting and host design. As current and previous coordinator of several EU Research Training Networks and as company founder, he has extensive experience in international training of researchers as well as in project management and business development.
Publications
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2024 | Article in journal
Rational Design and Evaluation of Photoactive Molecularly Imprinted Nanoparticles for Tetracycline Degradation Under Visible Light
Yadiris Garcia, Joao Aguilar, Laura Polania, Yorley Duarte, Börje Sellergren, Veronica A. Jimenez
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2024 | Article in journal
Rational Design of Highly Selective Sialyllactose-Imprinted Nanogels
Cecilia Contardi, Liliia Mavliutova, Massimo Serra, Davide Rubes, Rossella Dorati, Giulio Vistoli, Alessio Macorano, Börje Sellergren, Ersilia De Lorenzi
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2024 | Article in journal
Molecularly imprinted nanogels as synthetic recognition materials for the ultrasensitive detection of periodontal disease biomarkers
Thomas Hix Janssens, Julia R Davies, Nicholas W. Turner, Börje Sellergren, Mark V. Sullivan
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2024 | Article in journal
Affinity Capillary Electrophoresis as a Tool To Characterize Molecularly Imprinted Nanogels in Solution
Cecilia Contardi, Davide Rubes, Massimo Serra, Rossella Dorati, Marco Dattilo, Liliia Mavliutova, Maddalena Patrini, Raffaella Guglielmann, Börje Sellergren, Ersilia De Lorenzi
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2024 | Article in journal
Heteromultivalent Ligand Display on Reversible Self-Assembled Monolayers (rSAMs): A Fluidic Platform for Tunable Influenza Virus Recognition
Yulia Sergeeva, Sing Yee Yeung, Börje Sellergren
Research Projects
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Research project
Biomimetic sensors for monitoring of Norovirus and SARS-CoV-2 genetic variants in water
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Doctoral Project
Biomimetic SARS-C oV-2 receptors as host cell models, diagnostic tools and for antiviral research
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Research project
Investigation of multivalent pathogen inhibition and sensing using rSAM-based decoy nanoparticles
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Research project
Detection and sensing of predictive biomarkers for periodontitis