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Börje
Sellergren
Professor, directly appointed
borje.sellergren@mau.se
+46 40 665 78 10
orcid.org/0000-0002-2392-3305
Presentation
Professor Sellergrens research expertise span over supramolecular chemistry, molecular recognition and separation science. Based on rational chemical design, molecular self-assembly and imprinting, abiotic receptors are designed and used in affinity techniques for molecular biomarker analysis and discovery, pathogen inhibition and sensing, cell imaging, extracellular matrix imitations and therapeutics. Both “lock-and-key” and multivalent recognition concepts are being pursued. In the former case, molecular imprinting is used to produce robust receptors (MIPs), often exhibiting antibody-like recognition behaviour with nanomolar or higher affinities for biomolecular targets. Larger objects such as viruses or cells are instead targeted using dynamic multivalent receptors in the form of reversible self-assembled monolayers (rSAMs). This membrane mimetic plug and play approach is used to design dynamic virus or bacterial receptors featuring exceptionally high affinities that are currently explored as inhibitors, cell modulators or sensors. Sellergren has published over 190 scientific publications and 15 patents (H-index: 62) in the field of molecular imprinting and biomimetic chemistry with notable contributions reporting robust lipid bilayer mimetics, protein and peptide imprinting, PTM affinity engineering, combinatorial imprinting and host design. As current and previous coordinator of several EU Research Training Networks and as company founder, he has extensive experience in international training of researchers as well as in project management and business development.
Publications
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2024 | Article in journal
Affinity Capillary Electrophoresis as a Tool To Characterize Molecularly Imprinted Nanogels in Solution
Cecilia Contardi, Davide Rubes, Massimo Serra, Rossella Dorati, Marco Dattilo, Liliia Mavliutova, Maddalena Patrini, Raffaella Guglielmann, Börje Sellergren, Ersilia De Lorenzi
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2024 | Article in journal
Heteromultivalent Ligand Display on Reversible Self-Assembled Monolayers (rSAMs): A Fluidic Platform for Tunable Influenza Virus Recognition
Yulia Sergeeva, Sing Yee Yeung, Börje Sellergren
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2023 | Article in journal
Elucidation of the Binding Orientation in α2,3- and α2,6-Linked Neu5Ac-Gal Epitopes toward a Hydrophilic Molecularly Imprinted Monolith.
Chau Minh Huynh, Liliia Mavliutova, Tobias Sparrman, Börje Sellergren, Knut Irgum
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2023 | Article in journal
Towards molecularly imprinted polymers that respond to and capture phosphorylated tyrosine epitopes using fluorescent bis-urea and bis-imidazolium receptors.
Evgeniia Kislenko, Anil Incel, Kornelia Gawlitza, Börje Sellergren, Knut Rurack
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2023 | Article in journal
Enhanced selective capture of phosphomonoester lipids enabling highly sensitive detection of sphingosine 1-phosphate
Giuliana Grasso, Eduardo M Sommella, Fabrizio Merciai, Rahma Abouhany, Sudhirkumar A Shinde, Pietro Campiglia, Börje Sellergren, Carlo Crescenzi
Research Projects
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Research project
Biomimetic sensors for monitoring of Norovirus and SARS-CoV-2 genetic variants in water
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Doctoral Project
Biomimetic SARS-C oV-2 receptors as host cell models, diagnostic tools and for antiviral research
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Research project
Investigation of multivalent pathogen inhibition and sensing using rSAM-based decoy nanoparticles
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Research project
Detection and sensing of predictive biomarkers for periodontitis